About Dr. Melville
Stephen B. Melville Department of Biological Sciences, Virginia Tech |
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Research and Professional Experience: 1981-1982: Undergraduate Research Assistant, San Diego State University. Awards and Honors: 1980-1982: Academic scholarship, San Diego State University Publications: Orsburn, B., Sucre, K., Popham D. L.., and Melville S. B. 2008. The SpmA/B and DacF proteins of Clostridium perfringens play important roles in spore heat resistance. FEMS Microbiol Lett. In Press. Varga, J. J., Therit, B. H., and Melville, S. B. . 2008. Type IV pili and the CcpA protein are needed for maximal biofilm formation by the gram-positive anaerobic pathogen Clostridium perfringens. Infect Immun B:4944-4951 . Orsburn B., Melville, S. B., and. Popham D. L. 2008. Factors contributing to heat resistance of Clostridium perfringens endospores. Appl Environ Microbiol. 74:3328-3335. O’Brien, D. K., Therit, B. H., Woodman, M. E, and. Melville S. B. 2007. The role of neutrophils and monocytic cells in controlling the initiation of Clostridium perfringens gas gangrene infections. FEMS Immunol. Med. Microbiol. 50:86-93. Varga, J. J., Nguyen, V., O'Brien, D. K., Rodgers, K., Walker, R. A. and Melville, S. B. (2006) Type IV pili-dependent gliding motility in the Gram-positive pathogen Clostridium perfringens and other Clostridia. Mol. Microbiol. 62 (3): 680-694. Myers, G. S., D. A. Rasko, J. K. Cheung, J. Ravel, R. Seshadri, R. T. Deboy, Q. Ren, J. Varga, M. M. Awad, L. M. Brinkac, S. C. Daugherty, D. H. Haft, R. J. Dodson, R. Madupu, W. C. Nelson, M. J. Rosovitz, S. A. Sullivan, H. Khouri, G. I. Dimitrov, K. L. Watkins, S. Mulligan, J. Benton, D. Radune, D. J. Fisher, H. S. Atkins, T. Hiscox, B. H. Jost, S. J. Billington, J. G. Songer, B. A. McClane, R. W. Titball, J. I. Rood, S. B. Melville, and I. T. Paulsen. 2006. Skewed genomic variability in strains of the toxigenic bacterial pathogen, Clostridium perfringens. Genome Res 16:1031-40. Mastropaolo M. D., N. P. Evans, M. K. Byrnes, A. M. Stevens, J. L. Robertson, and S. B. Melville. 2005. Synergy in polymicrobial infections in a mouse model for type 2 diabetes. Infect Immun. Sep;73(9):6055-63. David K. O’Brien and S. B. Melville. 2004. Effects of Clostridium perfringens alpha-toxin (PLC) and perfringolysin O (PFO) on cytotoxicity to macrophages, on escape from the phagosomes of macrophages, and on persistence of C. perfringens in host tissues. Infect Immun. 72:5204-5215. Varga J, V. L. Stirewalt, and S. B. Melville. 2004. The CcpA protein is necessary for efficient sporulation and enterotoxin gene (cpe) regulation in Clostridium perfringens. J Bacteriol. 186:5221-5229 David K. O’Brien and S. B. Melville. 2003. Multiple effects on Clostridium perfringens binding, uptake and trafficking to lysosomes by inhibitors to macrophage phagocytosis receptors. Microbiology, 149: 1377-1386. O’Brien, D. K. and S. B. Melville. 2000. The anaerobic pathogen Clostridium perfringens can escape the phagosome of macrophages under aerobic conditions. Cell. Microbiol. 2: 505-519. Walters, D. M., V. L. Stirewalt, and S. B. Melville. 1999. Cloning, sequence and transcriptional regulation of the operon encoding a putative N-acetylmannosamine-6-P epimerase (nanE) and sialic acid lyase (nanA) in Clostridium perfringens. J. Bacteriol. 181:4526-4532. Zhao, Y. and S. B. Melville. 1998. Identification and characterization of sporulation-dependent promoters upstream of the enterotoxin gene (cpe) of Clostridium perfringens. J. Bacteriol. 180:136-142. Cotter, P., S. B. Melville, J. Albrecht, and R. P. Gunsalus. 1997. Aerobic regulation of the cytochrome d (cydAB) operon expression in Escherichia coli: roles of FNR and ArcA in repression and activation. Mol. Microbiol. 25:605-615. Melville, S. B. and R. P. Gunsalus. 1996. Isolation of an oxygen responsive FNR protein of Escherichia coli: interaction at activator and repressor sites of FNR controlled genes. Proc. Natl. Acad. Sci. 93:1226-1231. Melville, S. B., R. Labbe, and A. L. Sonenshein. 1994. Expression from the Clostridium perfringens cpe promoter in C. perfringens and Bacillus subtilis. Infect. Immun. 62:5550-5558. Melville, S. B. and R. P. Gunsalus. 1990. Mutations in fnr that alter anaerobic regulation of electron transport-associated genes in Escherichia coli. J. Biol. Chem. 265:18733-18736. Melville, S. B., T. A. Michel, and J. M. Macy. 1988. Pathway and sites for energy conservation in the metabolism of glucose by Selenomonas ruminantium. J. Bacteriol. 170:5298-5304. Melville, S. B., T. A. Michel, and J. M. Macy. 1988. Regulation of carbon flow in Selenomonas ruminantium grown in glucose-limited continuous culture. J. Bacteriol. 170:5305-5311. Melville, S. B., T. A. Michel, and J. M. Macy. 1987. Involvement of D-lactate and lactic acid racemase in the metabolism of glucose by Selenomonas ruminantium. FEMS Microbiol. Lett. 40:289-293. |
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